内容摘要：Performers from Luxembourg, Denmark, Armenia, Finland, Latvia, Lithuania and Greece also advanced to the final.

Performers from Luxembourg, Denmark, Armenia, Finland, Latvia, Lithuania and Greece also advanced to the final.

The process starts with modifying genes in pig skin cells in a lab. Revivicor initially deleted a gene that produces a sugar named, which triggers immediate destruction from the human immune system. Next came three-gene “knockouts,” to remove other immune-triggering red flags. Now the company is focusing on 10 gene edits — deleted pig genes and added human ones that together lessen risk of rejection and blood clots plus limit organ size.

They clone pigs with those alterations, similar to how Dolly the sheep was created.Twice a week, slaughterhouses ship Revivicor hundreds of eggs retrieved from sow ovaries. Working in the dark with the light-sensitive eggs, scientists peer through a microscope while suctioning out the maternal DNA. Then they slip in the genetic modifications.A worker at United Therapeutics’ designated pathogen-free facility in Christiansburg, Va., on May 29, 2024 retrives a UV sterilized item from behind a protected barrier within the facility. (AP Photo/Shelby Lum)

A worker at United Therapeutics’ designated pathogen-free facility in Christiansburg, Va., on May 29, 2024 retrives a UV sterilized item from behind a protected barrier within the facility. (AP Photo/Shelby Lum)“Tuck it in nice and smooth,” murmurs senior researcher Lori Sorrells, pushing to just the right spot without rupturing the egg. Mild electric shocks fuse in the new DNA and activate embryo growth.

Ayares, a molecular geneticist who heads Revivicor and helped create the world’s first cloned pigs in 2000, says the technique is “like playing two video games at the same time,” holding the egg in place with one hand and manipulating it with the other. The company’s first modified pig, the

single gene knockout, now is bred instead of cloned. If xenotransplantation eventually works, other pigs with the desired gene combinations would be, too.The team ruled him out for the game by the start of the second period.

As for the Hurricanes, they again played without two of their top six defensemen in Jalen Chatfield and Sean Walker. Chatfield hadn’t played since Game 4 of the second-round series against conference top seed Washington, missing five straight games with an apparent lower-body injury.Walker has missed the past two games since taking a jarring. open-ice hit from Greer in Game 2.

Coach Rod Brind’Amour was unsure whether either could be an option for this series even if the Hurricanes somehow pushed it far enough.“I was hopeful Chatfield being more day to day, but he just still hasn’t got in there with us,” Brind’Amour said before the game. “Until he’s out there I guess practicing with us, he’s not an option. Walker, same thing.”